Topic: Dr AIDS: Scientists discover potential drug to block AIDS  (Read 2889 times)

0 Members and 1 Guest are viewing this topic.

Dr AIDS: Scientists discover potential drug to block AIDS
« on: December 30, 2013, 05:31:43 PM »
Scientist at the Gladstone Institutes have identified the precise chain of molecular events in the human body that drives the death of most of the immune system’s CD4 T cells as an HIV infection leads to AIDS.

A typical scene at an emergency ward of a Lagos State government hospital before the protracted doctors strike.

Further, they have identified an existing anti-inflammatory drug that in laboratory tests blocks the death of these cells — and now are planning a Phase 2 clinical trial to determine if this drug or a similar drug can prevent HIV-infected people from developing AIDS.

Two separate journal articles, published simultaneously in Nature and Science, detail the research from the laboratory of Dr. Warner C. Greene, who directs virology and immunology research at Gladstone, an independent biomedical-research nonprofit.

His lab’s Science paper reveals how, during an HIV infection, a protein known as IFI16 senses fragments of HIV DNA in abortively infected immune cells. This triggers the activation of the human enzyme caspase-1 and leads to pyroptosis, a fiery and highly inflammatory form of cell death.

As revealed in Nature, this repetitive cycle of abortive infection, cell death, inflammation and recruitment of additional CD4 T cells to the infection “hot zone” ultimately destroys the immune system and causes AIDS.

“Gladstone has showed how the body’s own immune response to HIV causes CD4 T cell death via a pathway triggering inflammation, and secondly by identifying the host DNA sensor that detects the viral DNA and triggers this death response,” said Dr. Robert F.

Cure in the making .... IndiaTimes

 

Related Topics

  Subject / Started by Replies Last post
0 Replies
1773 Views
Last post October 09, 2012, 08:10:33 PM
by olaniyi
0 Replies
1547 Views
Last post January 14, 2013, 10:15:43 AM
by olaniyi
0 Replies
2639 Views
Last post January 25, 2013, 04:29:56 PM
by dayod247
0 Replies
1557 Views
Last post March 06, 2013, 10:25:52 AM
by olaniyi
0 Replies
1547 Views
Last post August 19, 2013, 02:25:53 PM
by ayo2
0 Replies
2344 Views
Last post January 28, 2014, 09:42:06 PM
by olaniyi
0 Replies
1629 Views
Last post April 12, 2017, 01:01:59 PM
by NaijaPilot
0 Replies
811 Views
Last post June 29, 2017, 07:03:38 AM
by thisday
0 Replies
1030 Views
Last post July 26, 2017, 07:02:09 PM
by flukky-1
0 Replies
1375 Views
Last post October 23, 2017, 07:02:12 PM
by olutee